Bdes De~nitive Report Autoantibodies Produced Spontaneously by Young lpr Mice Carry Transforiiiing Growth Factor ~ and Suppress Cytotoxic T Lymphocyte Responses
نویسنده
چکیده
Young MRL/MPJ-Ipr (1pr) mice 8-12 wk old challenged with alloantigen had significantly lower specific cytolytic T lymphocyte (CTL) responses than control MRL/MPJ +/+ mice. Serum from lpr mice compared with serum from + + or normal C3H mice powerfully suppressed CTL responses in mixed lymphocyte cultures (MLC); absorbing lpr serum on protein G, adding antibody against transforming growth factor fl (TGF-fl) to cultures or dissociating immunoglobulin G (IgG) and TGF-fi before additions to cultures prevented suppression. Apparently autoantibody, similar to IgG produced by normal mice in response to immunization, carries TGF-fl which suppresses CTL responses in vivo and in vitro.
منابع مشابه
Autoantibodies produced spontaneously by young 1pr mice carry transforming growth factor beta and suppress cytotoxic T lymphocyte responses
Young MRL/MPJ-lpr (lpr) mice 8-12 wk old challenged with alloantigen had significantly lower specific cytolytic T lymphocyte (CTL) responses than control MRL/MPJ +/+ mice. Serum from lpr mice compared with serum from ++ or normal C3H mice powerfully suppressed CTL responses in mixed lymphocyte cultures (MLC); absorbing lpr serum on protein G, adding antibody against transforming growth factor b...
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